Clinical Trials of Antifungal Prophylaxis in Surgical Critically Ill Patients
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منابع مشابه
Single-drug therapy or selective decontamination of the digestive tract as antifungal prophylaxis in critically ill patients: a systematic review
INTRODUCTION The objective of this study was to determine and compare the effectiveness of different prophylactic antifungal therapies in critically ill patients on the incidence of yeast colonisation, infection, candidemia, and hospital mortality. METHODS A systematic review was conducted of prospective trials including adult non-neutropenic patients, comparing single-drug antifungal prophyl...
متن کاملAntifungal agents for preventing fungal infections in non-neutropenic critically ill and surgical patients: systematic review and meta-analysis of randomized clinical trials.
OBJECTIVES This study aims to systematically identify and summarize the effects of antifungal prophylaxis in non-neutropenic critically ill adult patients on all-cause mortality and the incidence of invasive fungal infections. METHODS Systematic review and meta-analysis of randomized controlled trials in all languages comparing the prophylactic use of any antifungal agent or regimen with plac...
متن کاملFluconazole prophylaxis in critically ill surgical patients: a meta-analysis.
OBJECTIVE To evaluate the impact of fluconazole prophylaxis on the incidence of fungal infections and on mortality among critically ill surgical patients. DESIGN Meta-analysis of randomized, placebo-controlled trials of fluconazole prophylaxis. PATIENTS Subjects participating in the clinical trials in this area. MEASUREMENTS AND MAIN RESULTS We identified four randomized studies comparing...
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Fungi are a frequent cause of nosocomial infections, with an incidence that has increased significantly in recent years, especially among critically ill patients who require intensive care unit (ICU) admission. Among ICU patients, postsurgical patients have a higher risk of Candida infections in the bloodstream. In consideration of the high incidence of fungal infections in these patients, thei...
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Critically ill patients often suffer from disturbance of sleep-wake cycle and consequently delirium development, in intensive care units (ICU). In this study, we aimed to evaluate the effect of exogenous melatonin on delirium development and its related adverse sequelae in the subgroup of medical and surgical ICU patients. We performed a double-blind placebo-controlled randomized pilot study i...
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تاریخ انتشار 2007